Risks of Formula Feeding

Infants’ formulas have a higher concentration of nutrients and vitamins than those in breastmilk. This is in compensation for their reduced bioavailability to offset their reduced absorption and to ensure their presence throughout the entire shelf life of the product. Commercial artificial baby milks have many similarities to each other, but can differ significantly from each other in the quality and quantity of nutrients and in other additives, even among those from the same manufacturer. They also have an expiration date, after which the product should be discarded.

Formula fed infants and children have increased risks and rates of:

  • Allergic disease
  • Asthma
  • Crohn’s disease
  • Ulcerative colitis
  • Type 1 (insulin-dependent) diabetes mellitus and type 2 diabetes
  • Acute lymphoblastic leukemia and acute myeloblastic leukemia lymphomas
  • Necrotizing enterocolitis  (NEC)
  • Diarrheal disease
  • Otitis media
  • Lower respiratory tract illness (bronchiolitis, croup, bronchitis and pneumonia).
  • Obesity
  • Sudden infant death syndrome
  • Sepsis
  • Urinary tract infections


1. van Odijk J, Kull I, Borres MP, et al. Breastfeeding and allergic disease: a multidisciplinary review of the literature (1966-2001) on the mode of early feeding in infancy and its impact on later atopic manifestations. Allergy. 2003;58:833-843

2. Oddy WH, Holt PG, Sly PD, et al. Association between breastfeeding and asthma in 6 year old children: findings of a prospective birth cohort study. BMJ. 1999;319:815-819

3. .Koletzko B, Broekaert I, Demmelmair H, et al. Protein intake in the first year of life: a risk factor for later obesity? The EU childhood obesity project. Adv Exp Med Biol. 2005;569:69-79.

4. Corrao G, Tragnone A, Caprilli R, et al. Risk of inflammatory bowel disease attributable to smoking, oral contraception and breastfeeding in Italy: a nationwide case-control study. Cooperative Investigators of the Italian Group for the Study of the Colon and Rectum (GISC). Int J Epidemiol. 1998;27:397-404.

5. Sadauskaite-Kuehne V, Ludvigsson J, Padaiga Z, et al. Longer breastfeeding is an independent protective factor against development of type 1 diabetes mellitus in childhood. Diabetes Metab Res Rev. 2004;20:150-157.

6. Pettitt DJ, Forman MR, Hanson RL, Knowler WC, Bennett PH. Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians. Lancet. 1997;350:166-168.

7. Young TK, Martens PJ, Taback SP, Sellers EAC, Dean HJ, Cheang M, Flett B. Type 2 diabetes mellitus in children: Prenatal and early infancy risk factors among Native Canadians. Arch Pediatr Adolesc Med. 2002;156:651-655.

8. Kwan ML, Buffler PA, Abrams B, Kiley VA. Breastfeeding and the risk of childhood leukemia: a meta-analysis. Public Health Rep. 2004;119:521-535.

9. Shu XO, Linet MS, Steinbuch M, et al. Breastfeeding and the risk of childhood acute leukemia. J Natl Cancer Inst. 1999;91:1765-1772.

10. McNally RJ, Parker L. Environmental factors and childhood acute leukemias and lymphomas. Leuk Lymphoma. April 2006;47(4):583-98.

11. Updegrove K. Necrotizing enterocilitis: the evidence for the use of human milk in prevention and treatment. J Hum Lact. 2004;20:335-339.

12. Scariati PD, Grummer-Strawn LM, Fein SB. A longitudinal analysis of infant morbidity and the extent of breastfeeding in the United States. Pediatrics. 1997;99:e5.

13. Kvaavik E, Tell GS, Klepp KI. Surveys of Norwegian youth indicated that breastfeeding reduced subsequent risk of obesity. J Clin Epidemiol. 2005;58:849-855.

14. von Kries R, Koletzko B, Sauerwald T, et al. Breastfeeding and obesity: cross sectional study. BMJ. 1999;319:147-150.

15. Vennemann MM, Findeisen M, Butterfass-Bahloul T, et al. Modifiable risk factors for SIDS in Germany: results of GeSID. Acta Paediatr. 2005;94:655-660.

16. Hanson LA, Korotkova M. The role of breastfeeding in prevention of neonatal infection. Semin Neonatol. 2002;7:275-281